MMP2 (log2 fold change = 7.47), MMP9 (log2 fold change = 3.63), and TIMP2 (log2 fold change = 2.66) displayed increased expression in the TME, while MMP13 (log2 fold change = −4.41) and TIMP1 (log2 fold change = −2.26) displayed increased expression in the HCC tumor. The gene discussed is TIMP2; the disease is hepatocellular carcinoma.