FLT4 and hepatocellular carcinoma: Additionally in the VEGF family ligand-receptor interactions pathway, VEGFR1 (log2 fold change = −2.38) was upregulated in the HCC tumor while NRP1 (log2 fold change = 4.93), VEGFR2 (log2 fold change = 2.76), and VEGFR3 (log2 fold change = 3.21) were upregulated in the TME.