HCC tumor-derived ARNT (log2 fold change = −2.28) is a crucial gene involved in tumor progression that binds to Hif1α during hypoxic conditions to upregulate genes that contribute to invasion, metastasis, and neo angiogenesis (Tanimoto, 2000; Weir et al., 2011). This evidence concerns the gene HIF1A and hepatocellular carcinoma.