Chen et al. (2017) identified 6 hub genes, ABAT, AGXT, ALDH6A1, CYP4A11, DAO, and EHHADH, that were associated with HCC metastasis risk. Li et al. (2018) identified the 5 hub genes, GINS1, TOP2A, BUB1B, ARPC4, and ACADM in HCC progression with high node degree. The gene discussed is BUB1B; the disease is hepatocellular carcinoma.