Beside these general functions, alterations affecting protein post-translational modification, which might be related to hyperphosphorylation of tau (or of other proteins) (Tan et al., 2015), ubiquitination (Measho et al., 2018), glycosylation (Wang et al., 2017), or citrullination (Deolankar et al., 2019) of brain proteins characteristic of AD could be demonstrated. This evidence concerns the gene MAPT and Alzheimer disease.