Similarly, the other hub proteins were identified; the IGF-1 (Westwoo et al., 2014), EGF (Lei et al., 2012; Siddiqui et al., 2012), SERPINE1 (Akhter et al., 2018), and fibronectin (Anna et al., 2009) were linked earlier to aging, neurodegeneration, and AD. This evidence concerns the gene EGF and Alzheimer disease.