In addition, dual suppression of both PI3K-γ and colony stimulating factor-1/colony stimulating factor-1 receptor (CSF-1/CSF-1R) pathways in tumor associated macrophages (TAM) could remodel tumor immune microenvironment (TIME) and synergistically activate antitumor immune responses in pancreatic cancer (Li et al., 2020). This evidence concerns the gene CSF1 and neoplasm.