CSF1R and familial pancreatic carcinoma: In addition, dual suppression of both PI3K-γ and colony stimulating factor-1/colony stimulating factor-1 receptor (CSF-1/CSF-1R) pathways in tumor associated macrophages (TAM) could remodel tumor immune microenvironment (TIME) and synergistically activate antitumor immune responses in pancreatic cancer (Li et al., 2020).