TGFB1 and metabolic dysfunction-associated steatohepatitis: Myeloid-specific STING induced TGF-β1 and activated hepatic stellate cells (HSCs), which promoted NASH progression, whereas disruption of myeloid STING alleviated hepatic inflammation, steatosis, and liver fibrosis in a mouse model of HFD or methionine and choline-deficient diet (MCD)-induced NASH (72), suggesting that activation of STING regulates macrophage function and augments hepatic lipid accumulation, profibrotic gene expression, and proinflammatory responses in NASH (Figure 2).