In a study by Ricca et al. when testing if pre-existing immunity to Newcastle Disease Virus (NDV) increases the therapeutic efficacy of the oncolytic virus, they found that depletion of NK cells prior to initial immunization to NDV, decreased the therapeutic efficacy of NDV against tumors and NK cells are likely important for early tumor clearance, and recruitment and activation of CD8 T cells (112). Here, CD8A is linked to neoplasm.