In a phase I and II clinical trial HLA-mismatched anti-CD19 CAR-NK cells derived from cord blood was administered to patients with B-Lymphoid malignancies and saw a 73% response (206) and now early phase I clinical trials are further investigating CD19 and CD22 CAR-NK cells in Refractory B-cell Lymphoma patients, NCT03690310 and NCT03692767. The gene discussed is CD19; the disease is B-cell non-Hodgkin lymphoma.