Additionally, elevated levels of VWF were described as predictive of poor outcome for some vascular endothelial syndromes such as transplant-associated thrombotic microangiopathy (112, 113), and FVIII seems to be involved in the pathophysiology of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) after alloHSCT (114). This evidence concerns the gene VWF and hepatic veno-occlusive disease.