Absence of vitamin A or impaired RA signaling resulted in changes in the gene expression profile of ILC2s, e.g., decreased expression of the hexokinase-encoding gene hk2 and upregulated expression of Peroxisome proliferator-activated receptor alpha (Ppara), and ILC2s alternatively uptake more fatty acids to survive and resolve helminth infection (29). Here, PPARA is linked to helminthiasis.