RHO and Parkinson disease: Similarly, in the neurodegenerative Parkinson’s disease (PD), α-synuclein aggregates are associated with the induction of neurotoxicity by activation of microglia that leads to NOX2 (NADPH oxidase) activation and ROS production via Src-Erk- and Rho-dependent pathways (177, 178), where CD11b-/- microglia are better protected (179).