Our review shows that 29 dysregulated miRNA in HBV-HCC (Table 1) are both regulated and regulate epigenetic changes offering numerous hypotheses to be tested in vitro. In the case of our four HBV-HCC pathways, miR-101 influences PRC2 and DNMT3A silencing, miR-148/152influenced DNMT1/3A silencing, miR-155 repressed PRC2 silencing and miR-29a/b repressed DNMT1/3A silencing in parallel with affecting immune expression in both the innate and adaptive immune systems. Here, DNMT3A is linked to hepatocellular carcinoma.