It has been demonstrated that HBx-downregulated miR-101 fails to modulate DNMT3A expression in HBV-HCC and this can contribute to the silencing of tumor suppressor genes like SF1/PRDM2/GSTP1/RUNX3/APC/CDKN2A/STMN1 (24, 149). This evidence concerns the gene CDKN2A and hepatocellular carcinoma.