In percentage terms, common host genes targeted for DNA methylation in HBV-HCC include WT1 (54%), SOCS1 (43-65%), SEMA3B (83%), RASSF1A (59-75%), p300 (65%), p27 (48%), p21 (63%), p16 (16-83%), GSTP1 (41-76%), E-cadherin (33-67%), E2F1 (70%), CPS1 (80%) and APC (53-81%) (10). This evidence concerns the gene CDKN2A and hepatocellular carcinoma.