RUNX3 and hepatocellular carcinoma: DNMT3A/3B also silences many tumor suppressors in HBV-HCC pathways like RASSF1/PRDM2/GSTP1/RUNX3/APC therefore, miR-29 induced DNMT3A/3B repression contributes to a secondary support system for tumor suppressor expression to slow HCC progression (172).