SOCS1 and hepatocellular carcinoma: Furthermore, SOCS1 which regulates type I IFN signaling, is targeted by miR-155 in macrophages (211, 212) and the loss of function of SOCS-1 is a common feature in HCC clearly supporting a hypothesis that HBx-upregulated miR-155 promotes the progression of HBV-HCC (200, 201).