Our data showed that knockdown of C/EBPβ remarkably decreased COX-2 expression (Figure 3F) and PGE2 secretion (Figure 3G), suggesting that C/EBPβ is the key transcription factor for COX-2 and PGE2 production in microglia induced by HP-PRRSV infection. The gene discussed is CEBPB; the disease is infection.