However, Vδ1+ T cells are dominant in the TME of ESCC, possibly because activated Vδ1+ γδT cells in peripheral blood can adhere to ESCC cells and fibroblasts via adhesion molecules, including LFA-1 (CD11a), CD49d, CD49e, L-selectin, and CD103, whereas Vδ2 T cells can only use a few adhesion molecules, including LFA-1, L-selectin, and CD44v6 (31). The gene discussed is ITGAL; the disease is esophageal squamous cell carcinoma.