Additionally, MCP-1 expression levels in the TME are positively correlated with increased stromal cell and TAM CC chemokine receptor 2 (CCR2) expression, associated with tumor invasion depth, lymph node metastasis, and distant metastasis, and predict poor prognosis in patients with ESCC (45–47). The gene discussed is CCR2; the disease is esophageal squamous cell carcinoma.