CXCL8 and neoplasm: By changing the esophageal microenvironment and gut bacteria, a high-fat diet can cause esophageal dysplasia, which promotes the development of BE into EAC, which involves IL-8 chemokine family activation and neutrophil recruitment, along with NK cell reduction, suggesting that increased neutrophils may inhibit NK cell-mediated tumor cell cytotoxicity and indicate poor prognosis (93).