AKT1 and psoriasis: Previous studies by our group have shown that PSORI-CM02 ameliorates the skin symptoms of IMQ-induced psoriasis by regulating T cell balance and reducing inflammatory cytokine secretion (17, 18), promoting M2-type macrophage polarisation (20), and inhibiting the phosphorylation of components of the PI3K/Akt/mTOR pathway to promote epidermal autophagy (19).