Our previous study found that PSORI-CM02 inhibits the proliferation of HaCaT cells and reduces the psoriasis area and severity index scores in mice with imiquimod (IMQ)-induced psoriasis (17), regulates the T cell balance (17, 18), inhibits the phosphorylation of components of the PI3K/Akt/mTOR pathway to promote autophagy (19), inhibits the NF-κB signalling pathway and inflammatory factor secretion (17), and promotes M2-type macrophage polarisation (20). This evidence concerns the gene AKT1 and psoriasis.