The loss of M tuberculosis specific CD4+ T-cells and inability of producing perforin by CD8+ T-cells during acute HIV infection (12–14), and impaired phagolysosomal fusion, autophagy mediated inhibition of M tuberculosis and impaired generation of antimicrobial peptide and mycobactericidal reactive radicals in HIV- M tuberculosis co-infected macrophages are considered to increase the risk of TB (15–20). The gene discussed is CD4; the disease is tuberculosis.