IFNG and hepatocellular carcinoma: In HCC, the NK cell frequency within the tumour-infiltrating lymphocyte compartment is less than in the non-tumour tissue, and these intratumoral cells demonstrate impaired cytotoxicity and IFN-γ production (43, 81), We have also previously demonstrated that there is a parallel increase in NK cells and Treg in hepatic inflammation (82) suggesting that taming the Treg population will allow NK cells to function more efficiently.