IL27 and hepatocellular carcinoma: Specific clinical trials looking at patients with HCC include looking at the use of SRF388 which is a fully human IgG1 antibody against IL-27 that decreases the expression of inhibitory immune checkpoint receptors (https://clinicaltrials.gov/ct2/show/NCT04374877?term=TIGIT+HCC&draw=2&rank=).