CHRNA7 and preeclampsia: In conclusion, abnormal low α7nAChR activity on dMφ along with a decrease in M2 dMφ and an increase in M1 dMφ existed in human PE and the mouse model of PE induced by LPS, which indicated that the suppression of α7nAChR might result in preeclampsia possibly through the M1 dMφ-triggered excessive maternal–fetal inflammatory response.