In pregnancy-induced hypertension (PIH), higher mRNA levels of TNF-α and IL-1β, lower mRNA levels of IL-4, IL-10, and IL-13 were observed in macrophages differentiated from isolated peripheral blood mononuclear cells than that in normotensive pregnancies (45); the percentage of CD86-positive macrophages (M1) was higher and percentage of CD163-positive macrophages (M2) was lower in PIH group than that in control group (45). The gene discussed is TNF; the disease is hypertension, pregnancy-induced.