Surprisingly, when genes closely associated to desmosomes (Supplementary Tables 1, 2) were analyzed, only two of 13 genes, DSG3 and DSC2, were upregulated twofold or more in acute and chronic lesions of AD and PSO patients (Figures 3A,B,D and Supplementary Figure 2C) (2). This evidence concerns the gene DSG3 and Alzheimer disease.