In this study, treatment with selective inhibitors against Nlrp3 inflammasome displayed rescue effects on DENV- and rEIII-induced platelet cell death in vitro and thrombocytopenia in mice, suggesting that Nlrp3 inflammasome is a potential target for the therapeutic intervention of DENV-induced platelet defects. This evidence concerns the gene NLRP3 and Thrombocytopenia.