The inhibition of T cell proliferation and production of Th1 cytokines (IFN-γ and TNF) was also demonstrated in in vitro studies involving human B10 and IL-10+ transitional B cells; however, B cells from patients with autoimmune diseases such as SLE, RA, and type 1 diabetes are unable to achieve this suppression (26, 30, 67, 95, 202, 203). The gene discussed is IL10; the disease is systemic lupus erythematosus.