On the other hand, stimulation of mouse B cells with an agonistic anti-CD40 antibody in vitro and in vivo leads to an increase in IL-10+ Bregs able to suppress arthritis and lupus in murine models (3, 94), while B cells overexpressing CD40L exhibit higher frequencies of B10 (31). The gene discussed is CD40; the disease is systemic lupus erythematosus.