While the amount of IP-10 induced in the first 24 h by infection with the VSV M51R mutant in 1205Lu cells exceeded the amount induced by VSV wt by up to 100-fold, there was no difference in its dependence on RIG-I and MAVS without major contributions by MDA5 or PKR (see Supplementary Figures S6 and S1). Here, RIGI is linked to infection.