Using CRISPR-Cas9 edited loss of function variants of the human melanoma cell line 1205Lu, we confirmed that in the experimental system used in this study, the early induction of interferon-stimulated cytokines by VSV is RIG-I- and MAVS-dependent but does not require MDA5 or PKR (see Supplementary Figure S1). This evidence concerns the gene EIF2AK2 and melanoma.