Based on histopathological features, immunohistochemistry and clinical data, various GvHD-like changes were observed in the skin: parakeratosis, dyskeratosis, intensive basal layer destruction, intracellular oedema, subepidermal atypic lymphocyte T infiltration without features of malignancy (CD3+, CD4+>CD8+ at a ratio of 1.5-2:0, incidental CD30+), and focal destruction of skin appendages (Figure 3A) despite the lack of HSCT or organ transplantation in the patient’s past medical history. This evidence concerns the gene CD4 and graft versus host disease.