CD4 and malaria: The limited duration of the host protective immunity against the malaria parasite may also be explained by the parasite, inducing the apoptosis of LLPCs, MBCs, and activated CD4+ T cells (Figure 3; Hirunpetcharat and Good, 1998; Wipasa et al., 2001; Xu et al., 2002; Wykes et al., 2005).