Although HIV-1 induction of apoptosis in bystander CD4+ T cells was reported to be driven by Env glycoproteins, gp120 and gp41 (Blanco et al., 2003), Env-mediated autophagy during HIV-1 early infection was first described in 2006 (Espert et al., 2006). The gene discussed is CD4; the disease is infection.