High baseline serum C-Reactive Protein (PCR) and interleukin 6 (IL-6) levels, as well as hypoadiponectinemia and hyperleptinemia/leptin resistance (typical of obesity) elucidates the preexisting inflammatory microenvironment in obese patients, making them more susceptible to worse outcomes and even fatality. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.