LEP and obesity due to melanocortin 4 receptor deficiency: High baseline serum C-Reactive Protein (PCR) and interleukin 6 (IL-6) levels, as well as hypoadiponectinemia and hyperleptinemia/leptin resistance (typical of obesity) elucidates the preexisting inflammatory microenvironment in obese patients, making them more susceptible to worse outcomes and even fatality.