APOE and dementia: After adjustment for demographics, education, income, BMI, depressive symptoms, smoking, alcohol use, physical activity, comorbidities, APOE4 genotype, and baseline MMSE, those with a bedtime of before 9 p.m. were almost three times more likely to develop dementia [HR=2.16 (95%CI: 1.06–4.40)], compared to those going to bed between 9 and 11 p.m. Later bedtime (i.e., after 11 p.m.)showed the opposite but had a non-significant association with dementia risk (unadjusted HR = 0.24, 95%CI 0.03–1.80; adjusted HR in model 1=0.24, 95% CI 0.03–1.81; adjusted HR in model 2 = 0.15, 95%CI: 0.02–1.29).