The “early birds” (who reported going to bed earlier) had a lower education level, were less likely to be smokers and drinkers, less likely to do physical activity, more likely to have hypertension or diabetes, more likely to be an APOE e4 carrier, and had lower MMSE scores at baseline and follow-up compared to the “night owls” (who reported going to bed later). This evidence concerns the gene APOE and hypertensive disorder.