Though there was no significant difference in plasma DβH activity between first-episode and multi-episode patients, the multi-episode patients showed a decrease trend compared with first-episode patients in both MDD (14.45 ± 8.96 and 17.87 ± 13.91, respectively) and BD (13.32 ± 7.35 and 15.10 ± 9.66, respectively). The gene discussed is DBH; the disease is Behcet disease.