NLRP3 and liver dysplastic nodule: Similarly, activation of the NLRP3 inflammasome is also observed in mice with STZ-induced DN (Hou et al., 2020) or in db/db mice (Yi et al., 2017), and inhibition of NLRP3 inflammasome activation by chemical treatment or gene knockout alleviated renal inflammation and pathological progression in mice with DN (Ding et al., 2018; Wu et al., 2018).