VEGFA and colorectal cancer: A significant body of evidence is available that COX-2-derived PGE2 may play a role in tumor angiogenesis by increasing vascular endothelial growth factor (VEGF; Eibl et al., 2003), and recent data strongly suggest a contribution of platelet COX-1-derived thromboxane in colorectal cancer (Patrignani and Patrono, 2018).