Proteins namely von Willebrand factor (VWF), haptoglobin-related protein (HPR), glutathione peroxidase 3 (GPX3), alpha-2-macroglobulin (A2M), carbonic anhydrase 2 (CA2), protein S100-A8 (S100A8), carboxypeptidase B2 (CPB2), heparin cofactor 2 (SERPIND1), fibrinogen gamma chain (FGG), profilin-1 (PFN1), and serum amyloid A-4 protein (SAA4) were found to be significantly upregulated in the COVID-19 positive patients. The gene discussed is CA2; the disease is COVID-19.