Marshall’s (Marshall, 1998) concept of the “gut-liver axis” points out that when the intestinal mucosa is damaged, the permeability of the intestine increases and harmful bacteria and their metabolites [lipopolysaccharide (LPS) and endotoxins] enter the portal vein and move to the liver with blood circulation (“leaky gut”) (Marshall, 1998; Kamada et al., 2013; Nakamoto et al., 2017), activate the liver’s immune response, and release inflammatory cytokines such as IL-6, IL-1β, TNF-α, etc., thereby accelerate the progression of liver fibrosis (Lau et al., 2015). This evidence concerns the gene TNF and Hepatic fibrosis.