CHRNA7 and early-onset autosomal dominant Alzheimer disease: The protective effect of α7nAChR on several central nervous system diseases, such as ischemic stroke, hemorrhagic stroke, multiple sclerosis, and Alzheimer’s disease, has been demonstrated in substantial studies (Duris et al., 2011; Cheng et al., 2013; Guo et al., 2017; Shao et al., 2017).