To determine the specific regulators responsible for the m6A modification in the Mmp24 mRNA, we first examined the expression of m6A modification-related methyltransferases, including METTL3, METTL14, and WTAP, and demethylases, including FTO and ALKBH5 in the spinal cord under neuropathic pain condition. This evidence concerns the gene METTL3 and neuropathic pain.