KRAS and cancer: Importantly, mutant KRAS was shown to affect composition of EVs released by cancer cells and its DNA and protein molecules were detected in EVs from blood and pleural effusion of different cancers (Table 1) (Demory Beckler et al., 2013; Park et al., 2013; Kahlert et al., 2014; Lee et al., 2014; Yang S. et al., 2017; Möhrmann et al., 2018).