It has been demonstrated that DC-derived exosomes contain MFGE8, CD63, Toll-like receptors, adhesion molecules, co-stimulatory molecules, MHC-peptide complexes, and miRNA, which regulate the immune function of DCs, macrophages and lymphocytes during sepsis (Segura et al., 2005; Miksa et al., 2006; Miksa et al., 2009; Alexander et al., 2015; Zhang et al., 2019a; Lindenbergh et al., 2019). This evidence concerns the gene MFGE8 and Sepsis.