In this proteomics, we noticed 10 common DEPs in Mod: Con and SMI: Mod groups (Table 3) according to the Venn diagram analysis, and six of them, carboxylic ester hydrolase (ProteinID-D4AA05), UMP-CMP kinase (ProteinID-Q4KM73), uncharacterized protein (ProteinID-M0R5J4), glyceraldehyde-3-phosphate dehydrogenase (ProteinID-M0R590), Fas apoptotic inhibitory molecule 3 (ProteinID-Q5M871), and RCG21066 (ProteinID-D3ZJW6), were significantly up- or downregulated in serum of ISO-induced myocardial ischemia rats while were significantly back-regulated in serum of SMI pretreatment rats. The gene discussed is FCMR; the disease is myocardial ischemia.