MTOR and hypertensive disorder: In conclusion, this present study demonstrated that SNT could induce high blood pressure and left ventricular dysfunction in mice and cell viability loss in H9c2 cardiomyocytes via inhibition of autophagic flux, whereas EMPA was shown to alleviate the negative effects caused by SNT via regulating AMPK–mTOR signaling pathway–mediated cardiomyocyte autophagy.