As shown in Figures 5, 6, TB treatment caused acute upregulation of active caspase-3, Bax, and PTEN mRNA expression in a dose-dependent manner both in the HOG and U251 cells, as well as an increase of the proapoptotic gene Bax and downregulated the antiapoptotic gene Bcl2 (Figures 5A, 6A). This evidence concerns the gene BCL2 and tuberculosis.