ICAM1 and Arthritis: By reducing neutrophil recruitment and production of the inflammatory cytokines, BCA attenuated the development of zymosan-induced arthritis in mice (Felix et al., 2020), which correlates with the lower expression of adhesion molecules (VCAM-1, ICAM-1, and E-selectin) in neutrophils treated with BCA in vitro (Ming et al., 2015).