GPR30 activation has been shown to mediate anti-inflammatory protective effects in neuroinflammation (Guan et al., 2017), vascular inflammation (Chakrabarti and Davidge, 2012), and asthma (Itoga et al., 2015) and decreased the expression of TLR4 in murine macrophages induced by LPS (Rettew et al., 2010). This evidence concerns the gene TLR4 and asthma.