Gancainin H and liquorice glycide E (from liquorice) act on ACE2, and glycyrin targets IL-6 and GM-CSF, orchestrating multiple signaling pathways to attenuate inflammation and viral infection, thus preventing lung and heart injury caused by SARS-CoV-2 (Shi-Ying et al., 2020). The gene discussed is IL6; the disease is viral infectious disease.