It is also debatable whether atorvastatin played an anti-inflammatory role and reduced atherosclerosis by activating P2X7 receptors in endothelial cells, which is contradictory to the results of inflammation caused by endothelial P2X7 receptor activation (Mistafa et al., 2008; Lombardi et al., 2017). This evidence concerns the gene P2RX7 and atherosclerosis.