Interestingly, IL-1β antagonist significantly reduced blood pressure in one kidney/deoxycorticosterone acetate (DOCA)/salt-induced hypertension in rats, despite the fact that monoclonal antibody against IL-1β did not reduce blood pressure or incident hypertension during follow-up in CANTOS (Ling et al., 2017; Ridker et al., 2017; Rothman et al., 2020). This evidence concerns the gene IL1B and Hypertension.