Interestingly, a novel inhibitor of P2X7 receptor PKT100 improved the right ventricle (RV) contractility and systolic function and survival in the PAH mice model induced by bleomycin, with no effect on pulmonary arterial pressure and pulmonary vascular remodeling (Hansen et al., 2020). The gene discussed is P2RX7; the disease is pulmonary arterial hypertension.