Studies have shown that p53 was elevated in kidney cortex of diabetic rodents (Tikoo et al., 2008; Deshpande et al., 2013; Guo et al., 2018) and is elevated in renal biopsies of DN patients (Saito et al., 2016), while acetylation of p53 is essential for its stabilization and function (Brooks et al., 2003). The gene discussed is TP53; the disease is liver dysplastic nodule.