NR1I2 and thyroid gland papillary carcinoma: Also, polymorphisms affecting both UGT1A9 (UGT1A9-rs3832043) and nuclear receptor PXR (NR1I2-rs3814055, NR1I2-rs2472677, and NR1I2-rs10934498), possibly resulting in downregulation of liver metabolizing enzymes of Sorafenib (i.e., CYP and UGT), were associated with both plasma overexposure and severe thyroid toxicities upon Sorafenib intake in papillary thyroid cancer (Ba et al., 2020).