FN1 and renal fibrosis: Similarly, in vitro and in vivo, our results also showed that HK-2 cells treated with HG or diabetic rats induced by STZ increased the protein levels of fibrosis genes including coi I, coi IV, FN, and LN, and renal tubular epithelial destruction, glomerular hypertrophy, mesangial expansion, and renal fibrosis were observed in diabetic rats.