The critical role of ROS and reactive nitrogen species (RNS) in the development of schizophrenia and its progression towards thyroid disorders is evident by the enzymatic and non-enzymatic antioxidants profile including SOD (μg/dl), GSH (μg/dl), CAT (μmol/mol of protein), GPx (mmol/dl) and GR (μmol/ml) respectively. The gene discussed is SOD1; the disease is schizophrenia.