SNCA and Parkinson disease: One of these identified a heterozygous autosomal dominant point mutation in the SNCA gene (c.158C > A; p. A53E in transcripts NM_000345.3, NM_001146054.1, NC_000004.11), in two Finnish related PD patients characterized by severe bradykinesia, very slight tremor and early onset of LID (Martikainen et al., 2015).