BRCA1 and breast carcinoma: Breast cancer susceptibility gene 1/2 (BRCA1/2), one of the most comprehensively studied familial breast cancer hereditary factors, is frequently mutated in not only breast cancer (Tereschenko et al., 2002; Calderón-Garcidueñas et al., 2005) but also in other types of cancers, including prostate, ovarian, pancreatic cancer, and so on (Dutil et al., 2012; Kimberly et al., 2013), contributing to the pathogenicity of these malignancies (Kuchenbaecker et al., 2017).