In addition, compared with the IMQ group, the protein expression of IL-17a (p = 0.008) and TNF-α (p = 0.016) in the back lesions decreased in the IMQ + TDG group on day 12 (Figure 4A), which are inflammatory factors involved in the pathogenesis of psoriasis (Hawkes et al., 2017). This evidence concerns the gene TNF and psoriasis.