In addition to our previous report demonstrating that Fyn is a key player of DAergic degeneration by activating PKCδ via tyrosine phosphorylation (Saminathan et al., 2011), we also recently reported on Fyn’s role during microglial neuroinflammatory signaling events, thereby further broadening the significance of Fyn in PD (Panicker et al., 2015; Panicker et al., 2019). This evidence concerns the gene PRKCD and Parkinson disease.