They demonstrated that key pathophysiological circumstances in ALI like inflammatory reactions, IL-1β production, epithelial barrier permeability, remodeling and fibrosis are diminished in the lungs of Vim−/−mice when they were confronted with bleomycin, lipopolysaccharide or subjected to asbestosis (dos Santos et al., 2015). The gene discussed is IL1B; the disease is asbestosis.