PPARGC1A and chronic kidney disease: Lim et al. (2012) showed that PGC‐1α expression was decreased in the kidneys of aged mice; moreover, a recent study demonstrated that the activation of SIRT1 and AMPK by an agonist of PPARα, known as fenofibrate, increased the expression of PGC‐1α and ERRα improving mitochondrial dysfunction in aged kidneys (Kim et al., 2016). Therefore, reestablishing PGC‐1α expression could be a promising therapeutic strategy to counteract senescence and progression of CKD (Lee et al., 2019).