TXN and Hyperglycemia: The quercetin and resveratrol were associated with increased expression levels of antioxidants and can reduce aging markers in embryonic kidney cell line in hyperglycemia conditions; furthermore, the gene expression of Sirtuin 1 and thioredoxin (Trx) in all treated groups in comparison with control group increased in a dose-dependent fashion (Abharzanjani et al., 2017).