Indeed, PGC‐1α expression is highly decreased in different preclinical models of AKI, including cisplatin‐induced renal damage (Morigi et al., 2015) (Portilla et al., 2002), folate (Ruiz-Andres et al., 2016), IRI‐ (Portilla et al., 2002; Lempiäinen et al., 2013), and lipopolysaccharide (LPS)‐induced AKI (Tran et al., 2011). This evidence concerns the gene PPARGC1A and acute kidney injury.