Moreover, the decreased expression of PGC-1α is correlated with a reduced efficiency of mitochondrial biogenesis in AKI (Tran et al., 2011; Lynch et al., 2018) and in CKD (Lim et al., 2012; Galvan et al., 2017; Chung et al., 2018). Here, PPARGC1A is linked to acute kidney injury.